Abstract
Obesity is associated with greater risk and incidence of nephropathy. Mixed conjugated linoleic acid (CLA) isomers have beneficial effects on renal disease, but the effect of individual CLA isomers is not known. Our objective was to test whether dietary CLA isomers would alter renal injury progression in the obese fa/fa Zucker rat. Male obese and lean 17 wk old fa/fa Zucker rats were given diets with either 0.4% c9, t11 CLA, 0.4% t10, c12 CLA or control diet for 8 wk, after which renal function and histology were assessed. The dietary t10, c12 CLA decreased the glomerular volume, worsened the glomerulosclerosis and increased macrophage infiltration compared with control. In the t10, c12 CLA group, there was a trend for increased kidney weight, proteinuria, kidney fibrosis and tubular injury (tubular atrophy, calcification and casts) and reduced creatinine clearance, but these were not statistically different from control. The dietary c9, t11 CLA group had smaller glomeruli than control, and less glomerulosclerosis, fibrosis and macrophage infiltration compared with the t10, c12 CLA group. Hence, t10, c12 CLA exacerbates renal injury associated with obesity, while c9, t11 CLA does not, and may be protective. (Supported by Manitoba Agriculture Food and Rural Development Initiative, Dairy Farmers of Canada and NSERC)
Published Version
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