Abstract
Diabetes mellitus (DM) is typically a disorder of carbohydrate, fat, and protein metabolism. It develops due to a lack of or loss associated with insulin and/or resistance to insulin. Regarding complications of chemical substance use, drugs with few complications and high-reliability tannins are needed. This study aimed to determine the effect and mechanism of action of Citrullus colocynthis extract on the formation of glycated hemoglobin (HbA1c). A solution containing hemoglobin and glucose was incubated for 1, 2, 3, 4, 30, and 60 days by adding Citrullus colocynthis extract or glutathione. Quantitative measurement of HbA1c was performed using ion-exchange chromatography. Data were analyzed using ANOVA and two-way repeated measures test. A p<0.05 was considered statistically significant. The Citrullus colocynthis extract in hyperglycemic conditions and with increasing time reduced the formation of HbA1c and thus inhibited the production of glycated proteins. By increasing the time and after initiation of reaction of extract concentrations (0, 0.1, 0.3, 0.5, and 1 g/dL), presently, there was a significant decrease in the formation of HbA1C compared to those in the control group (p<0.05). The decrease in glycation has been dose dependent. Therefore, Citrullus colocynthis could directly reduce the formation of HbA1c.
Highlights
Diabetes is a common endocrine disorder worldwide with increasing incidence and one of the five main causes of death among countries [1]
The Citrullus colocynthis extract in hyperglycemic conditions and with increasing time reduced the formation of HbA1c and inhibited the production of glycated proteins
In type II diabetes, the most important cause of the disease is resistance to insulin, which results in a decrease in response to insulin in tissues and increase in hepatic glucose production that leads to hyperglycemia
Summary
Diabetes is a common endocrine disorder worldwide with increasing incidence and one of the five main causes of death among countries [1]. In type II diabetes, the most important cause of the disease is resistance to insulin, which results in a decrease in response to insulin in tissues and increase in hepatic glucose production that leads to hyperglycemia. This type of diabetes is the most common form in human societies and frequently observed in individuals aged >40 years and those with obesity [4]. The incidence of diabetes increases with insulin secretion disorder, insulin resistance, and overproduction of hepatic glucose (fasting hyperglycemia) [5]. It is possible that Maillard reaction occurs between proteins and
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