Abstract
Objective To investigate the value of endothelial progenitor cells (EPCs) in predicting the prognosis of ischemic cerebrovascular disease and mortality in the elderly. Methods A total of 100 elderly patients with ischemic cerebrovascular disease were recruited from the outpatient medical checkup division of our hospital. Clinical data including age, gender, blood pressure, blood glucose, blood lipids, medical history and medications were collected. Circulating EPCs were identified as cell surface markers CD34/CD133 double-positive cells using flow cytometry analysis. Patients were divided into the low and high groups based on the counts of circulating EPCs. After 18 months of follow-up, we evaluated the occurrence of cerebrovascular events. Results There were no significant statistical differences in age, gender, blood pressure, blood lipids, disease history, risk factors or treatment history between the two groups (all P>0.05). The incidences of first hospitalization and cerebrovascular events were higher in the high group than in the low group (both P 0.05). Conclusions Circulating endothelial progenitor cell levels can be considered as a predictor for ischemic cerebrovascular events in the elderly and may be helpful in early prevention and intervention of ischemic cerebrovascular disease in elderly patients. Key words: Endothelial cells; Stem cells; Cerebrovascular disorders; Prognosis
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