Abstract
Objective To investigate the effect of intracranial pressure fluctuation on the prognosis of patients with traumatic brain injury (TBI). Methods A retrospective case series study was conducted on the clinical data of 30 patients with TBI hospitalized between June 2012 and June 2014. There were 21 males and 9 females, aged (43.0±19.8)years. After the intracranial pressure probe was implanted, the intracranial pressure of TBI patients was monitored continuously and the data were recorded per minute. A single cosine method was used in analyzing the circadian rhythm of intracranial pressure data. Furthermore, the ratio of the amplitude of the circadian parameter (A) to the median (M) value (A/M) was selected to evaluate the biologic rhythm of patients. The correlations of circadian rhythm parameter A/M with Glasgow Outcome Scale (GCS) and with extended Glasgow Outcome Scale (GOS-E) were analyzed using linear regression. Results The circadian rhythm was observed in all patients regardless of injury severity (P<0.01). The circadian rhythm parameter A/M of intracranial pressure was positively correlated with the GCS of patients at discharge (R2=0.346, F=14.797, P<0.01) and with the GOS-E (R2=0.356, F=15.502, P<0.01). Conclusion The intracranial pressure fluctuation of TBI patients follows circadian rhythm, which might be correlated with the prognosis of TBI patients. Key words: Brain injuries; Intracranial pressure; Prognosis; Biorhythm
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