Abstract
To determine the effect of the new quinolone ciprofloxacin on airway ciliary motility, we studied ciliary beat frequency (CBF) of rabbit tracheal epithelium using an in-vitro microphoto-oscillation method. Incubation of the cells with ciprofloxacin increased CBF in a concentration-dependent manner, the maximal increase from the baseline value and the EC50 being 17.1 +/- 2.0% (P < 0.01) and 10(-7.25) M, respectively. This ciliary stimulatory effect was not affected by propranolol or indomethacin but was nullified by verapamil. These results suggest that ciprofloxacin probably increases airway epithelial ciliary motility by facilitating Ca2+ influx through a voltage-dependent channel.
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