Abstract
Background: Dyslipidemia is one of the important causes of cardiovascular disease related mortality and morbidity. Recently it has become a significant issue in public health problem of developing countries. The purpose of the study was to find a suitable solution for reducing blood lipid in dyslipidemic patients by conducting a research on the effect of cinnamon in hypercholesterolemic rats. Objective: To study the lipid lowering effect of Cinnamomum cassia on experimentally induced hypercholesterolemic rats. Materials and Methods: This study was done on 30 male Long Evans rats weighing about 200--210 gram. For convenience, the study was divided into two experiments --- Experiment I and Experiment II. In experiment I, 12 animals were divided into two groups. One was Group A (n = 6, control group) fed on laboratory diet and the other was Group B (n = 6) fed on laboratory diet and cinnamon for 35 days. In experiment II, the remaining 18 rats were fed fatty mixture diet containing 1% cholesterol and 0.25% cholic acid. The hypercholesterolemic rats were then divided into 3 groups, Group C, D, and E (n=6 in each group). Group D and Group E were additionally fed on cinnamon powder and tablet atorvastatin for 35 days respectively. Serum TC, TG, LDL-C and HDL-C were measured after 35 days. Results: Fatty mixture diet increased TG, TC and LDL-C significantly. Cinnamon treated fatty mixture diet group showed that Cinnamomum cassia decreased plasma TC, TG and LDL-C. Atorvastatin therapy decreased TC, TG and LDL-C levels significantly compared with the lowering effect of cinnamon. Conclusion: The results of this experimental study indicate that Cinnamomum cassia can act as a hypocholesterolemic agent and thereby can improve cardiovascular functions. Journal of Enam Medical College; Vol 3 No 2 July 2013; Page 94-98 DOI: http://dx.doi.org/10.3329/jemc.v3i2.16132
Highlights
Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood
Increased generation of oxidized LDL is a major factor in the vascular damage associated with high cholesterol levels
The inhibition of oxidative stress under hypercholesterolemic conditions is considered to be an important therapeutic approach and efforts have been made to identify the antioxidative functions of various medicinal plants.[1]
Summary
Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood. Assistant Professor, Department of Pharmacology and Therapeutics, Enam Medical College, Savar, Dhaka 3. Associate Professor, Department of Pharmacology and Therapeutics, Enam Medical College, Savar, Dhaka 4. Assistant Professor, Department of Pharmacology and Therapeutics, Sir Salimullah Medical College, Dhaka 6. Assistant Professor, Department of Pharmacology and Therapeutics, Northern International Medical College, Recently, hypercholesterolemia has been associated with enhanced oxidative stress related to increased lipid peroxidation. Objective: To study the lipid lowering effect of Cinnamomum cassia on experimentally induced hypercholesterolemic rats. Cinnamon treated fatty mixture diet group showed that Cinnamomum cassia decreased plasma TC, TG and LDL-C. Atorvastatin therapy decreased TC, TG and LDL-C levels significantly compared with the lowering effect of cinnamon.
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