Effect of Cimetidine on Semen Parameters, FSH and LH in Male Rats

Abstract

Cimetidine is effective drugs on male reproductive system by its effect on semen characteristic or parameters such as sperm motility, sperm morphology and sperm count, and also cimetidine effect on sexual hormones, were effect on testosterone, FSH and LH. In this investigation, 20 male rats were randomly classified into two groups, Control group(G1): This group contain on 10 male rats receiving normal saline and Cimetidine group( G2): This group contain on 10 male rats receiving 100mg/kg. B.W. from cimetidine group, during the period 38days from(20. Novmber.2022 to 28. Desmber.2022), after end from study animals slaughtered, then, seminal samples were taken from the epididymis, as well as blood samples, and converted into serum for the purpose of work hormonal analysis. Group treated with cimetidine showed significantly decrease in sperm motility and increase in immotile sperm and also significantly increase in abnormal sperm morphology and decrease in normal, also this study showed significantly decrease in sperm counts. Also this study showed significantly decrease in level of testosterone and FSH, but increase in LH, it can be concluded that Cimetidine exerted a significant harmful effects on semen characteristics and sexual hormones.