Abstract
The purpose of this investigation was to determine the effect of acute cimetidine administration on the elimination kinetics of acetaminophen in rats. Cimetidine, 80 mg/kg i.p., 30 min before i.v. injection of acetaminophen, 30 mg/kg, caused a small but statistically significant decrease in the total clearance and an increase in the biological half-life of acetaminophen in adult male rats. The partial metabolic clearance of acetaminophen to acetaminophen sulfate was decreased by cimetidine. The magnitude of the acute interaction of cimetidine with acetaminophen was not increased at a higher (150 mg/kg) dose of acetaminophen.
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