Effect of cilostazol in experimental model of degloving injuries in rat limbs.

André Pazio,Vital Burko Santos,Guataçara Schenfelder Salles Junior

doi:10.1590/s0102-865020180040000001

Abstract

To evaluate the effect of the cilostazol on the evolution of partially avulsed flaps, using experimental model of cutaneous degloving in rat limbs. A controlled and randomized experimental study was carried out in which the blood flow and the percentage of flap necrosis were evaluated. We compared the study group, which received cilostazol, and the control group, which received enteral saline solution in the postoperative period. The blood flow in the flap was evaluated through Laser Doppler flowmetry, and a planimetry using the IMAGE J® software was employed for the calculation of the area of necrosis. Enteral administration of cilostazol was associated with a higher mean blood flow in all regions of the flap, with a statistically significant difference in the proximal and middle regions (p<0.001) and a lower percentage of necrotic area in the flap (p<0.001). Postoperative enteral administration of cilostazol increased blood flow and decreased the total area of necrosis of avulsed cutaneous flaps of rat limbs.

Highlights

Degloving injuries, called partial avulsions, are lesions that cause separation of skin and subcutaneous tissue from the underlying muscle and fascia
Nakamura et al.[13] demonstrated that Cilostazol induces vasodilation in the thoracic artery of rats by increasing nitrous oxide (NO) production in aortic endothelial cells
Many studies have evaluated the effect of Cilostazol on nitrous oxide synthesis and have demonstrated that it potentiates nitrous oxide synthesis induced by interleukin-1 beta (IL-1 beta), probably via cAMP-dependent pathways[14,15]

Summary

Introduction

Called partial avulsions, are lesions that cause separation of skin and subcutaneous tissue from the underlying muscle and fascia. Most degloved injuries occur on the extremities and chest, and are caused when the tissue is trapped between a fixed surface and a moving object, such as a road pavement and the wheel of a car[1,2]. Such injuries are more frequent in the young male population (male = 61.9%, mean age = 32.5 years), generating a high cost to society in relation to working days missed and treatment-related costs[3]. It is necessary to quickly restore the skin barrier function and avoid such complications[4]

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Results

Conclusion