Effect of Cigarette Smoke on Salivary Total Antioxidant Capacity.

Sedigheh Bakhtiari,Zahra Namazi,Masoumeh Mehdipour,Zahra Elmi,Somayyeh Azimi,Somayyeh Amini

doi:10.15171/joddd.2015.049

Sedigheh Bakhtiari, Zahra Namazi + Show 4 more

Open Access

https://doi.org/10.15171/joddd.2015.049

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Abstract

Background and aims. Cigarette smoke can induce oral cancer by its free radicals and oxidative damage. Salivary anti-oxidants system is believed to have an important role in defense mechanisms against oxidative stress. This study was compared total antioxidant capacity (TAoC) of saliva in smokers and nonsmokers.Materials and methods. In this cross-sectional study, 30 male smokers with mean age of 45.23 years and 30 nonsmokers with mean age of 45.30 years participated. Unstimulated whole saliva samples were collected in the morning in two groups by spitting method. TAoC of saliva was measured with the special kit in two groups at the same time. Statistical analysis was performed by covariance test.Results. The mean salivary TAoC in nonsmokers (0.741±0.123 U/ml) was higher than that in smokers (0.529±0.167 U/ml). This difference was statistically significant (P<0.001).Conclusion. Smoking can alter salivary antioxidant capacity.

Highlights

Cigarette smoke comprises several materials including carbon monoxide, nitrogen, nicotine, and free radicals such as superoxide, hydroxyl, hydrogen peroxide and reactive oxygen (O2-)
Antioxidants protect body against free radicals.10Salivary antioxidants is composed of molecules such as uric acid, glutathione, and enzymes,[8] including superoxide dismutase (SOD), catalase (CAT) peroxidase (POX) and glutathione peroxidase
The results showed the mean salivary total antioxidant capacity (TAoC) in nonsmokers was higher than smokers; and this difference was statistically significant (P

Summary

Introduction

Cigarette smoke comprises several materials including carbon monoxide, nitrogen, nicotine, and free radicals such as superoxide, hydroxyl, hydrogen peroxide and reactive oxygen (O2-) These compounds are associated with increased incidence of cancer in different parts of the body including the oral cavity.[1,2,3,4] Saliva is the first body liquid to come in contact with foreign substances or gases such as the cigarette smoke.[5] The saliva contains immunoglobulin and enzymes such as lactoferrin, lysozyme, and histamine. This study was performed to investigate the effect of smoking on salivary total antioxidant capacity (TAoC)

Materials and Methods

Results

Discussion

Conclusion