Abstract
The effect of chronic cigarette smoking on lipid peroxidation and antioxidant status in 100 newly diagnosed patients with gastric cancer was studied. Equal number of age- and sex-matched healthy control subjects was taken as control. The level of plasma and erythrocyte thiobarbituric acid reactive substances (TBARS) was markedly increased in both the gastric cancer patients when compared to control subjects. The activities of enzymatic and non-enzymatic antioxidants were significantly decreased in both (smokers and non-smokers) gastric cancer groups when compared to control subjects. Comparatively, the increased TBARS level and decreased antioxidants level was observed in smokers than non-smoking gastric cancer patients. The present study highlights the occurrence of lipid peroxidation and possible breakdown of antioxidant status in cigarette smoking, which may subsequently increase the possibility of initiation and progression of gastric cancer.
Highlights
Gastric cancer is a leading cause of illness and death from cancer worldwide, with nearly a million new cases diagnosed each year
Tobacco smoke contains a variety of carcinogen including N-nitroso compounds and nitrogen oxides that may promote endogenous formation of N-nitroso compounds, which have been linked to gastric carcinogenesis[5]
An increased number of hypertensive or diabetes was observed in gastric cancer patients compared with health control subjects
Summary
Gastric cancer is a leading cause of illness and death from cancer worldwide, with nearly a million new cases diagnosed each year. The present study was, undertaken to determine the effects of chronic smoking on the extent of lipid peroxidation and the status of antioxidants in gastric cancer patients. The levels of fasting blood glucose in gastric cancer patients and healthy control subjects did not differ significantly.
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