Abstract
Treatment of immature female rats with phenobarbital (37 mg/kg, ip, twice daily) for 3 days increases the activity of liver microsomal enzymes that metabolize 17β-estradiol. The stimulatory effect of chronic phenobarbital administration on in vitro estradiol metabolism is paralleled in vivo by a blockade in the estradiol-induced increase in uterine wet weight and the incorporation of glycine-14C into uterine protein. However, a single dose of phenobarbital (45 mg/kg, ip), given 1 hr before the estrogen, does not inhibit estradiol-induced increases in uterine wet weight. The inhibitory action of chronic phenobarbital treatment on the increase in uterine wet weight caused by estradiol is not prevented by adrenalectomy or hypophysectomy, indicating that phenobarbital does not act through the pituitary-adrenal axis. (Endocrinology 80:135,1967)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
