Abstract
Congestive heart failure is a multiple aetiology, high prevalence, poor prognosis cardiovascular disorder. Medical treatment of dilated cardiomiophaty is aimed at alleviating the symptoms of heart failure. Growth hormone (GH) and insulin like growth factor (IGF-1) are involved in several physiological processes such as the control of muscle mass and function, body composition and regulation of nutrient metabolism (1,2). The roles of GH and IGF-1 as modulators of myocardial structure and function are well established (3). Receptors for both GH and IGF-1 are expressed by cardiac myocytes; therefore, GH may act directly on the heart or via the induction of local or systemic IGF-1, while IGF-1 may act by endocrine, paracrine or autocrine mechanisms.
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