Abstract
The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored the relationship between F concentrations in bone and plasma. Thirty male mice were randomised into three groups: Group I (No-F, No-Exercise), Group II (50 ppmF, No-Exercise), Group III (50 ppmF, Exercise). Body weight and physical performance of all mice were measured at baseline and end of experiment. F concentrations of plasma and bone were measured at the end of experiment. Mean plasma F concentration was significantly higher (p < 0.001) in Groups II and III compared with Group I. Mean bone F concentration was also significantly higher (p < 0.01) in Groups II and III compared with Group I. There was a significant correlation (p = 0.01, r = 0.54) between F concentration of plasma and bone. Mean body weight of Group I mice was significantly higher than Group II (p < 0.001) and Group III (p = 0.001) mice at the end of the experiment. This study, which provides the first data on the effect of chronic exercise on F metabolism in fluorosis-susceptible mice, suggests no effect of chronic exercise on F in plasma and bone. However, exposure to high-F resulted in lower body weight and exercise capacity in mice.
Highlights
Fluoride (F) is considered a beneficial nutrient, present in trace amounts in the body[1] and of public health significance due to its role in mineralisation of both teeth and bones
Among the factors influencing F metabolism, little evidence is available on the effects of exercise and genetics on F metabolism and body retention
A recent human experimental study reported higher plasma F concentrations with moderate and vigorous intensity exercise compared with a non-exercised control in young adults after an acute session of exercise at different intensities, as well as reduction in urinary F excretion after moderate intensity exercise compared with the control group[8]
Summary
Fluoride (F) is considered a beneficial nutrient, present in trace amounts in the body[1] and of public health significance due to its role in mineralisation of both teeth and bones. The effectiveness of topical exposure to even low F concentrations (
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