Abstract
1. 1. The nature and extent of changes in levels of liver metabolites, as a result of chronic ethanol consumption, were investigated using miniature swine as experimental subjects. 2. 2. Mean ethanol consumption was in excess of 6.0 g ethanol/kg body weight per day. 3. 3. Mean hepatic tissue concentrations of triglycerides, NADH and β-hydroxybutyrate, as well as the β-hydroxybutyrate/acetoacetate ratio, were greater for pigs fed ethanol than for controls. 4. 4. Mean hepatic tissue levels of glycogen and ATP, as well as the NAD +/NADH ratio and energy charge, were less for pigs fed ethanol than for controls.
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