Abstract
Rats were pretreated with a single dose of reserpine (10 mg/kg i.p.) oe were gioven daily injections of chlorpromazine (15 mg/kg s.c.) for 3 weeks. Controls received distilled water. 72 h after reserphine and 1 week after withdrawal from chlorpromazine apomorphine was administered (10 mg/kg i.p.). Both the intensity and duration of apomorphine-induced stereotyped behavior (ASB) and the concentration of apomorphine in brain were measured. Further groups of rats pretreated with reserpine of chlorpromazine as well as corresponding controls, received 0.25 mg/kg apomorphine and the development of ASB was rated. 14 of 16 reserpine-pretreated rats and 4 of 16 control rats developed ASB after 0.25 mg/kg apomorphine ( p < 0.001). After withdrawal from chlorpromazine, apomorphine (0.25 mg/kg) induced ASB in 12 out of 14 experimental and 5 out of 14 control rats ( p < 0.05). Following 10 mg/kg of apomorphine there was a significant ebhancdement of motor activity associated with ASB in rats exposed to reserpine or withdrawn from chlorpromazine, compared to controls. This enhancement could notbe explained by differences in brain apomorphine concentrations. The results are not inconsistent with the concept of neuroleptic-induced supersensitivity of dopamine receptors.
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