Abstract
Almost all of the important pathophysiological targets for ethanol in the nervous system appear to be specific membrane proteins involved in signal transduction. In this paper we have examined levels and functionality of the α subunit of the Go protein (Goα) in cerebral cortex and cerebellum from rats that have chronically ingested ethanol, by using immunoblotting and pertussis toxin-catalyzed ADP-ribosylation experiments. Goα protein levels were increased in plasma membranes from the two brain areas, and this increase was shown to specifically affect Go 1α, one of the two isoforms of the Goα subunit. Results obtained here lead us to suggest that increased Go 1α in plasma membranes would counteract a modified and non-functional protein generated during chronic alcohol treatment.
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