Abstract
Effect of chronic administration of ethanolic extract of Acorus calamus (AC) was studied on spontaneous electrical activity and monoamine levels of brain. AC (200 mg/kg and 300 mg/kg) was administered orally to adult Holtzman strain rats for 14 days. In AC treated rats, electrographic recording revealed that there was increase in α activity together with an increase in norepinephrine level in the cerebral cortex but a decrease in the midbrain and cerebellum. Serotonin level was increased in the cerebral cortex but decreased in the midbrain. Similarly, dopamine level was increased in the caudate nucleus and midbrain but decreased in the cerebellum. Thus AC seems to exert its depressive action by changing electrical activity and by differentially altering brain monoamine levels in different brain regions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
