Abstract
The present research is aimed to characterize the potential efficiency of two chelators after chromium(VI) administration for 60 days following two doses of 15 and 30 mg kg-1 chromium(VI) per body weight daily to male rats. However, the hypothesis that the two chelators might be more efficient as combined therapy than as single therapy in removing chromium(VI) from bood serum was considered. In this way, two known chelators deferasirox and deferiprone were chosen and tested in the acute rat model. Two chelators were given orally as a single or combined therapy for a period of one week. Chromium(VI) and iron concentrations in blood were determined by flame atomic absorption spectroscopy method. Chromium is one of the most widely used industrial metals. Several million workers worldwide are estimated to be exposed to chromium compounds in an array of industries. Chromium(VI) is more readily absorbed by both inhalation and oral routes. Ingestion of large amounts of chromium(VI) can lead to severe respiratory, cardiovascular, gastrointestinal, hepatic and renal damage and potentially death. The combined chelation therapy results show that deferasirox and deferiprone are able to remove chromium(VI) ions from bood while iron concentration returned to the normal level and symptoms are also decreased.
Highlights
Chromium is an important metal, which is used in a variety of industrial applications e.g. textile dying, tanneries, metallurgy, metal electroplating, wood preserving and preparation of chromate compounds
Deferiprone can be given orally and its important property is its ability to penetrate cells, coordinate iron, forming a neutral complex, which is capable of permeating membranes (Glickstein et al, 2006)
The aim of the present work was to evaluate the ability of combined deferasirox and deferiprone in removing chromium from blood
Summary
Chromium is an important metal, which is used in a variety of industrial applications e.g. textile dying, tanneries, metallurgy, metal electroplating, wood preserving and preparation of chromate compounds. It large quantities of chromium have been discharged into the environment due to accidental releases or inadequate precautionary measures (Kimbrough et al, 1999). Chromium(VI) is known to enter cells readily via non-specific anion channels and it is thereafter reduced by intracellular reductants to the more stable Cr(III) with the concomitant formation of reactive intermediate species of Cr, Cr(V) and (IV) and Reactive Oxygen Species (ROS) These reactive species can cause DNA damage and lipid peroxidation (Bagchi et al, 2002; O’Brien et al, 2003). Removal of chromium and especially Chromium(VI), is an essential pollution abatement process that should be applied to all industrial effluents that contain this contaminant
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