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Abstract
The effect of various glycosidases on the growth of solid hypotetraploid Ehrlich ascites tumour was investigated. The purified bacterial chondroitinase-ABC significantly inhibited the growth of tumour; chondroitinase-AC inhibited the tumour to some extent but chondro-4-sulphatase, chondro-6-sulphatase, streptomyces hyaluronidase, and β-glucuronidase had no inhibitory effect. Heat-treated chondroitinase-ABC had no inhibitory effect on the tumour growth. The growth of tumour cells which were injected subcutaneously after in vitro incubation with chondroitinase-ABC or -AC solution was decreased when compared with that of sham-treated cells.The injection of 1 ml of chondroitin sulphate A and chondroitin sulphate C solution prior to tumour inoculation into the same site promoted the tumour growth, while growth-stimulating effect of chondroitin sulphate B was ambiguous. The chondroitin sulphate appears to serve as a growth supporter which protects the surface of tumour cells and promotes the physiological surface function of the cells.
Highlights
Summary.-The effect of various glycosidases on the growth of solid hypotetraploid Ehrlich ascites tumour was investigated
CHONDROITIN sulphate C promotes the growth of solid Ehrlich ascites tumour in viro, which correlates with the concentration of chondroitin sulphate used (Takeuchi, 1965, 1966a, 1966b, 1971)
Present data indicate that chondroitinase-ABC and -AC inhibit the growth of solid Ehrlich ascites tumour, and that chondro-4-sulphatase, chondro-6-sulphatase, streptomyces hyaluronidase and,?glucuronidase have no inhibitory effect on tumour growth
Summary
Summary.-The effect of various glycosidases on the growth of solid hypotetraploid Ehrlich ascites tumour was investigated. The purified bacterial chondroitinaseABC significantly inhibited the growth of tumour; chondroitinase-AC inhibited the tumour to some extent but chondro-4-sulphatase, chondro-6-sulphatase, streptomyces hyaluronidase, and f-glucuronidase had no inhibitory effect. The growth of tumour cells which were injected subcutaneously after in vitro incubation with chondroitinase-ABC or -AC solution was decreased when compared with that of sham-treated cells. CHONDROITIN sulphate C promotes the growth of solid Ehrlich ascites tumour in viro, which correlates with the concentration of chondroitin sulphate used (Takeuchi, 1965, 1966a, 1966b, 1971). Effects of purified chondroitinase-ABC, -AC, chondro-4-sulphatase, chondro-6-sulphatase, streptomyces hyaluronidase, 8-glucuronidase, and chondroitin sulphates A, B and C on the growth of solid Ehrlich ascites tumour were tested as previously described (Takeuchi, 1965, 1966a, 1966b, 1968, 1971)
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