Effect of Choline on Blood and Tissues with Especial Reference to Cholesterol in Old Hens.

Abstract

The lipotrophic activity of choline in experimental fatty cirrhosis of the liver, has been demonstrated by several groups of investigators.1,2,3 The possibility of similar action on other types of cholesterol deposition in other tissue, particularly in atheromatous lesions in the aorta, has suggested itself. The naturally occurring human-like subintimal aortic atheromatosis as reported by Dauber4a was chemically studied in 3-year-old certified 260 to 320 egg R.P.O. sired hens and the average level of certain chemical components established.4b The effect of choline on this pathological chemistry presented itself as an important problem.Steiner5 first and then Bauman and Rusch6 and about simultaneously Himsworth7 reported that they had not been able to demonstrate any action of choline on the high blood, aortic or liver content of cholesterol in cholesterol-fed rabbits. Andrews and Broun8 concluded that cholin protected against atherosclerosis and Huber, Broun, and Casey9 using lipocaic re ported the preven...