Abstract
Physicochemical properties of non-steroidal anti-inflammatory drugs (NSAIDs), salicylic acid and salicylamide, in choline chloride and urea based deep eutectic solvent (DES), reline, have been determined at temperature range from 288.15 to 313.15 K. In this work, physicochemical parameters such as apparent molar volume (Vϕ), apparent molar isentropic compressibility (Kϕ,s) and relative viscosities (ηr) are studied for the said NSAIDs in water and aqueous reline solutions. The results indicate that in all cases, the solute–solvent interactions increases with increasing concentration of DES as well as temperature. In addition, the values of viscosity B-coefficient are determined by analyzing Jones-Dole equation. Hepler’s constant (∂2V0ϕ/∂T2) and limiting apparent molar expansivity (E0ϕ) are deduced as well. Finally, the intermolecular interactions are evaluated by making plots among various parameters and discussed in terms of competing interactions present in the ternary systems.
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