Abstract
Abstract A highly efficient and ecofriendly co-solvency method using choline-based ionic liquids (ILs) as novel green solvents was developed to enhance the aqueous solubility of acetaminophen (ACP). ACP is a drug that is widely used as an antipyretic analgesic in clinical practice and its paediatric use is common. In this study the solubility of ACP in aqueous choline lactate (ChLa) and choline bitartrate (ChBi) solutions were measured at different temperatures for the first time. The temperature and solvent composition dependence of ACP solubility was analyzed through the some important semi-empirical and activity coefficient models acquiring the average relative deviation percent as e-NRTL (0.39%)
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