Abstract
The effect of cholecystokinin tetrapeptide amide (CCK-4) on the content of 5-hydroxytryptamine (5-HT) and its major metabolite, 5-hydroxyindole-3-acetic acid (5-HIAA), was studied in various regions of the brain of rat. After intracerebroventricular administration of CCK-4, the content of 5-HT decreased, while the content of 5-HIAA increased in some areas. These changes were marked 30 min after the injection and relatively small doses (10 and 100 ng) of CCK-4 produced a pronounced effect, but larger doses (1 and 10 μg) were less effective. The ratio of 5-HIAA/5-HT increased significantly in most regions of the brain, except in the striatum and the olfactory tubercle. The results indicate that exogenous CCK-4 in small doses stimulates the metabolism of 5-HT in the brain of rat.
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