Abstract

Following a single high dose of intraperitoneal administration of chlorpromazine (50 mg/kg) into adult male albino rats, tyrosine-α-ketoglutarate transaminase (TKT) and tryptophan pyrrolase (TP) activity of rat liver are increased near about 3-fold within 5 hr whereas threonine dehydrase (TD) activity increases maximally within 2 hr. Actinomycin D (Act. D) inhibits the chlorpromazine induced stimulation of all the three enzymes.

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