Abstract
The clinically active anti-psychotic drugs chlorpromazine, α-flupenthixol, (+) butaclamol and haloperidol specifically reduce the striatal p -tyramine ( p -TA) in the mouse. The m -tyramine ( m -TA) concentration was not changed and consequently a fall in the p -TA/ m -TA ratio was observed. In contrast, the structurally related compounds, promethazine, β-flupenthixol and (−) butaclamol, which lack antipsychotic properties, do not induce significant changes in the striatal tyramines concentration.
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