Abstract
Synthetic flavans, isoflavans and isoflavenes substituted with chloro, cyano and amidino groups were tested for their in vitro activity against poliovirus type 2, Coxsackie virus B4, echovirus type 6 and enterovirus 71. Plaque-reduction assays showed that substituted 3-(2 H)-isoflavenes, carrying a double bond in the oxygenated ring, possess antiviral activity higher than that of the corresponding isoflavans. The most effective compounds were 4′-chloro-6-cyanoflavan and 6-chloro-4′-cyanoflavan. Studies on the mechanism of action of these two compounds suggested an effect on the early stages of viral replication.
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