Abstract
Background: The combination of chlorhexidine (CHX) and fluoride is believed to enhance the effects of both constituent elements, and reduce their possible side effects. This study aimed to evaluate the effect of CHX containing sodium fluoride on dental plaque, gingival inflammation, and tooth discoloration. Methods: In this double-blind clinical study, 40 patients were selected and randomly divided into two groups. One group was given CHX 0.12%, and the other one was provided with sodium fluoride 0.05%-CHX 0.12% mouthwashes. Plaque index (PI), gingival index (GI), and discoloration index (DI) were measured at the beginning of the study and then after two weeks. Data were analyzed using chi-squared and independent t test. Results: PI and GI were significantly reduced in the group with CHX + sodium fluoride compared to the one with CHX (P<0.001); however, the difference between two groups in terms of DI was not statistically significant (P =0.08). Both groups showed complications, but their differences were not statistically significant (P=0.5). Conclusions: Mouth wash containing CHX + sodium fluoride was more effective in dental plaque control and gingival inflammation than the one only including CHX, although complications were not statistically significant between the two groups.
Highlights
The combination of chlorhexidine (CHX) and fluoride is believed to enhance the effects of both constituent elements, and reduce their possible side effects
Significant differences were found between the intervention groups regarding gingival index (GI) and Plaque index (PI) at baseline and after 15 days (P < 0.001)
It was detected that fluoride-containing CHX mouthwash significantly reduced gingival and plaque indices compared to those only containing CHX
Summary
The combination of chlorhexidine (CHX) and fluoride is believed to enhance the effects of both constituent elements, and reduce their possible side effects. This study aimed to evaluate the effect of CHX containing sodium fluoride on dental plaque, gingival inflammation, and tooth discoloration. Conclusions: Mouth wash containing CHX + sodium fluoride was more effective in dental plaque control and gingival inflammation than the one only including CHX, complications were not statistically significant between the two groups. Chlorhexidine (CHX) has been established as the gold standard in chemical plaque control, but it produces some side effects such as staining of teeth and alteration in taste sensation [4]. It is a biguanide agent, which damages the cellular transport of the bacterial cell in the lower concentration [1]. It has antimicrobial effects against periodontal and cariogenic pathogens [5]
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