Abstract
Carvacrol, a phenolic monoterpene present in the oregano essential oil. The aim of this study was to investigate the wound healing activity of carvacrol incorporated to chitosan bioactive films on excision wound model in rats. Wistar rats, weighing 250-300 g, were anesthetized and an excisional wound was performed. Rats were treated with chitosan bioactive film; chitosan bioactive film containg carvacrol 0.5% or 1%, for 3, 7, 14 or 21 days. The residual wounds were analyzed and removed. Serial histological sections were obtained and stained by histochemical techniques (Hematoxilin/Eosin and Sirius red). Experimental protocols were approved by the Animal Care and Use Committee at the UFS/Brazil. Carvacrol incorporated to chitosan films reduced wound areas (p < 0.01) and tissue edema (p < 0.001), induced earlier granulation tissue formation, increased cell proliferation, increased ephitelization rates (p < 0.01) and improved collagenization when compared to the control group. It is suggested that carvacrol incorporated to chitosan films has a potential use on skin wound healing of rats. Financial support: FAPITEC/SE/Brazil; CNPq/Brazil and CAPES/Brazil.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
