Abstract

To investigate the mechanisms of the many favorable properties of chitin membrane in woundhealing, human peripheral monocytes were cultured on chitin membrane or other wound dressing materials, and the chemical mediators from macrophage, including prostaglandin E2 and interleukin 1, were analyzed.These mediators were detected in the supernatants of the macrophage cultures. The chitin-induced productionof chemical mediators from macrophages was less than that induced by the other dressing materials.These results suggest that each wound dressing material has a different capability of inducing th productionof inflammatory chemical mediators by macrophages, and that the favorable properties of chitin in woundhealing might be related to its lower capability to induce localized inflammation.

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