Abstract
This paper discusses the mechanical and physicochemical properties of film matrices based on chitosan, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It is shown that with the introduction of chitin nanofibrils as a filler, the mechanical stability of the composite materials increases. By varying the concentration of chitin nanofibrils, it is possible to obtain a spectrum of samples with different bioactive properties for the growth of human dermal fibroblasts. Film matrices based on the nanocomposite of chitosan and 5 wt % chitin nanofibrils have an optimal balance of mechanical and physicochemical properties and bioactivity in relation to the culture of human dermal fibroblasts.
Highlights
Significant advancements have already been made in the development of biomaterials, regenerative technologies still demand polymer materials that can be processed without harming the environment, are biocompatible, biologically active, and capable of safe bioresorption.The biopolymers chitin (CN) and chitosan (CS) completely meet the above requirements; in addition to these properties, they have some other advantages, such as antibacterial and fungicidal activity, anesthetic, wound healing, and hemostatic properties [1].Two important physicochemical parameters of CS are its degree of deacetylation and its molecular mass
Use of high molecular mass chitosan is restricted in a number of areas since it has low solubility in water and diluted solutions of acids; besides, its solutions demonstrate high viscosities even at low concentrations
We studied the effect of chitin nanofibril additives on mechanical properties, moisture sorption, and surface charge of chitosan films
Summary
Two important physicochemical parameters of CS are its degree of deacetylation and its molecular mass. These characteristics have a significant influence on the properties of CS-based materials and, on their biomedical applications [2]. Use of high molecular mass chitosan is restricted in a number of areas since it has low solubility in water and diluted solutions of acids; besides, its solutions demonstrate high viscosities even at low concentrations. Low molecular mass chitosan samples have biomedical applications due to their high solubility in water and low viscosity of aqueous solutions at physiological pH values [3]
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