Abstract
Urban particulate matter (UPM) is a heterogenous mixture of various types of atmospheric particles. Exposure to UPM leading to adverse health effects is evaluated by using in vitro cultures of human alveolar epithelial cells. Cell viability showed a time‐ and concentration‐dependent decrease when exposed to UPM. UPM induced time‐dependent reactive oxygen species generation in the alveolar epithelial cell as measurements by 2′,7′‐dichlorofluorescein diacetate. NCI‐H441 cells, the human alveolar epithelial cell line, exposed UPM underwent an epithelial mesenchymal transition as evidenced by the up‐regulated expression of the mesenchymal‐specific proteins α‐smooth muscle actin and fibronectin. In addition, the potential role of chebulic acid in regulating UPM‐induced EMT was observed
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
