EFFECT OF CHANGES IN PHYSICAL ACTIVITY ON MARKERS OF BLOOD COAGULATION AND FIBRINOLYSIS

Abstract

1135 We examined the effects of changes in physical activity (PA) on markers of blood coagulation and fibrinolysis in 108 adults in the Seasonal Variation of Cholesterol Study [56% men, age=49±12.5 yrs, BMI=27.3±4.6 kg·m−2 (mean±SD)]. Fasting morning blood samples and PA measures were collected at baseline and then every 3 months for 1 year. Three 24-hour PA recalls were obtained at each assessment point to estimate total (TA), household (HA), occupational (OA), and leisure-time activity (LA) in MET-hrs·d−1. Baseline values of fibrinogen (FIBR), factor VIIc activity (FVIIc), and unbound plasminogen activator inhibitor-1 (PAI-1) were (mean ±SD); 306±83 mg·dl−1, 107±22%, and 55±43 ng·ml−1, respectively. Random effects models quantifying the slope (b) of the relationship between change in PA and change in FIBR, PAI-1, and FVIIc revealed that subjects reporting increases in TA had reductions in FIBR [b(men)=−0.65, (−1.7, 0.4); b(women)=−2.51, (−4.4, −0.6); (b, (95%CI)]. Increased LA was also associated with favorable reductions of FIBR in both men [b= −1.97, (−4.8, 0.4)] and women [b=−1.84, (−5.0, 1.3)]. In women only, increased OA and HA were associated with reduced FIBR levels [b=−2.05, (−5.8, 1.7) and b=−3.05, (−5.6, −0.5), respectively]. No associations were observed between any PA measure and PAI-1 or FVIIc. In conclusion, increased PA at home, at work, and during leisure-time may lower risk of cardiovascular events by favorably reducing basal levels of FIBR. Support: ACSM Fellowship for Epidemiological Research and NIH ROI HL-52745.