Abstract
Abstract Background To investigate the effect of changes in laboratory light intensity on chemistry and whole blood analysis. Materials and Methods The light intensity of the laboratory environment was measured and chemical and whole blood analysis was performed on 20 patient blood samples. The light intensity was then increased using projectors and re-measured, and the chemical and whole blood analyses were repeated. The values of the tests pre- and post-light increase were compared by statistical analysis using the Wilcoxon test. Results Increasing light from 195 to 1,168 lux significantly altered the results of the lipase, alkaline phosphatase, creatinine, and iron chemistry tests, (p<0.001 [11.3%], p=0.003 [2.2%], p=0.001 [2%] and p=<0.001 [1.2%], respectively). There was also a significant difference in platelet count (p=<0.001 [188%]). Conclusions We show that the platelet count is sensitive to changes in laboratory light intensity at clinically unacceptable levels. The lipase, alkaline phosphatase, creatinine and iron tests are also sensitive to changes in laboratory light intensity, but at clinically acceptable levels.
Highlights
Laboratory measurements always contain errors and uncertainties
The changes between the values reported in the pre- and postexperimental biochemical tests of LIP, alkaline phosphatase (ALP), CREAT, iron, creatine kinase (CK), gamma glutamyl transferase (GGT), lactate dehydrogenase (LDH) and direct bilirubin were 11.3, 2.2, 2, 1.2, 2.7, 2.9, 2.2, and 2.5%, respectively
A statistically significant difference was found in the analysis results of the LIP, ALP, CREAT and iron chemistry tests (p
Summary
Laboratory measurements always contain errors and uncertainties. It is not possible to perform a chemical analysis that is completely error-free and certain [1]. Instrumental and environmental noise is encountered in any analysis method that makes use of an instrument for measurement [4]. We aimed to investigate the effects of changes in laboratory light intensity on chemistry tests and whole blood analyses. To investigate the effect of changes in laboratory light intensity on chemistry and whole blood analysis. Materials and Methods: The light intensity of the laboratory environment was measured and chemical and whole blood analysis was performed on 20 patient blood samples. Conclusions: We show that the platelet count is sensitive to changes in laboratory light intensity at clinically unacceptable levels. The lipase, alkaline phosphatase, creatinine and iron tests are sensitive to changes in laboratory light intensity, but at clinically acceptable levels
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