Abstract
Background: There is an established link between the change in levels of Estrogen and its affect on mental health in middle age females. Objective: To see the correlation between serum Estrogen levels and cognitive functions in the study groups. Methods: This was a hospital based crosssectional study involving a total of 90 females who were divided into three groups of 30 females each, based on their age and menstrual history.These groups were premenopausal(31-35 years ) ,early perimenopausal( 36-40 years,),late perimenopausal (41- 45 years).The level of serum Estrogen was estimated in all the study subjects and their cognitive assessment was done using Montreal Cognitive Assessment scale(MoCA). One way ANOVA was used to asses the signicance. Results: There is a correlation between cognitive decline and serum estrogen levels in late perimenopausal age group as compared to early perimenopausal and premenopausal age group. Conclusion: There is a signicant relationship between estrogen levels and cognitive functions in middle aged females.
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