Abstract
The effect of various tablet formulation and processing factors on the rate of dissolution of the active ingredient of model tablets (prepared by double compression) was investigated. Dissolution rate increased with decreasing granule size (over the range 16-20 mesh to 60-80 mesh), but not strictly proportionally to the corresponding increase in the apparent surface area of the granules. Increasing starch content of granules (varied from 0 to 20 per cent) resulted in an increase in dissolution rate. Increasing precompression pressure (varied from 715 to 5720 Kg./cm.<sup>2</sup>) caused an increase in dissolution rate. This was probably due <i>to</i> fracturing of the harder granules into smaller particles with greater specific surface area or bonding of the softer granules (prepared at lower slugging pressure) during their compression into tablets.
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