Abstract
AbstractThe depressing effects of the extracts of Ocimun sanctum (O), Schizandra chinensis (S), Sedum rosea (R), Withania somnifera (W), Aralia elata (A), and Celastrus paniculatus (C) upon the mouse central nervous system (CNS) was evaluated. Recovery time of the righting reflex after the injection of a single dose of pentobarbital (50 mg/kg i.p.) was compared to the effect induced by that drug and the extracts. Decreasing or increasing the time for mouse recovery was evaluated in relation to dose and sex. The results demonstrate a significant (p ⩽ 0.05) increase of the narcosis time with all the extracts. The recovery of the righting reflex was sex and dose‐dependent. These plant extracts have a clear synergism with pentobarbital in depressing the mouse CNS response.
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