Effect of cerebrospinal fluid replacement combined with intrathecal injection on tuberculous meningitis and the levels of interleukin-8 and interferon-gamma in cerebrospinal fluid

Abstract

Objective To investigate the effect of cerebrospinal fluid replacement combined with intrathecal injection on tuberculous meningitis and the levels of interleukin-8 and interferon-gamma in cerebrospinal fluid. Methods 94 patients with tuberculous meningitis admitted to our hospital from January, 2015 to January, 2017 were selected as observation objects. According to the treatment methods, they were divided into a control group and a research group. The control group was given routine treatment. On this basis, the research group was given cerebrospinal fluid replacement and intrathecal injection. The curative effect, the times for the disappearance of clinical symptoms and the levels of interleukin-8 and interferon-gamma were compared between the two groups. Results The total effective rate was higher in the research group than in the control group (93.62% vs. 78.72%, P<0.05). The times for the disappearance of headache, body temperature increase, cerebrospinal fluid pressure increase, and meningeal irritation were (16.73±3.85) d, (13.65±3.07) d, (20.14±3.25) d, and (21.86±3.77) d in the research group, which were shorter than those in the control group (all P<0.05). After the treatment, the levels of interleukin-8 and interferon-gamma in the cerebrospinal fluid decreased in the two groups, and were (1 425.53±103.12) ng/L and (25.11±8.76) ng/L in the research group, which lower than those in the control group (P<0.05). Conclusion Cerebrospinal fluid replacement combined with intrathecal injection for tuberculous meningitis can improve the therapeutic effect and the patients’ clinical symptoms and levels of interleukin-8 and interferon-gamma in cerebrospinal fluid. Key words: Cerebrospinal fluid replacement; Intrathecal injection; Tuberculous meningitis; Cerebrospinal fluid interleukin-8; Interferon-gamma