Abstract
White blood cell counts (WBC), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) are used as chronic inflammation markers. Polycystic ovary syndrome (PCOS) is a constellation of systemic inflammation linked to central obesity (CO), hyperandrogenism, insulin resistance, and metabolic syndrome. The waist-to-height ratio (WHtR) constitutes a highest-concordance anthropometric CO measure. This study aims to access WBC, LMR, and MHR in PCOS and healthy subjects, with or without CO. Establishing relationships between complete blood count parameters, high-sensitivity C-reactive protein (hsCRP), and hormonal, lipid and glucose metabolism in PCOS. To do this, WBC, LMR, MHR, hsCRP, anthropometric, metabolic, and hormonal data were analyzed from 395 women of reproductive age, with and without, PCOS. Correlations between MHR, and dysmetabolism, hyperandrogenism, and inflammation variables were examined. No differences were found in WBC, LMR, MHR, and hsCRP between PCOS and controls (p > 0.05). PCOS subjects with CO had higher hsCRP, MHR, and WBC, and lower LMR vs. those without CO (p < 0.05). WBC and MHR were also higher in controls with CO vs. without CO (p < 0.001). MHR correlated with anthropometric, metabolic, and endocrine parameters in PCOS. WHtR appeared to strongly predict MHR in PCOS. We conclude that PCOS does not independently influence WBC or MHR when matched for CO. CO and dysmetabolism may modify MHR in PCOS and control groups.
Highlights
Polycystic ovary syndrome (PCOS) is a complex metabolic disorder that occurs in 15–20% of women of reproductive age [1]
Comparisons of hormonal and biochemical parameters between L-waist-to-height ratio (WHtR) and H-WHtR patients with PCOS and L-WHtR vs. H-WHtR CON were presented in Table 2; Table 3
The assessment of anthropometric, biochemical and inflammatory parameters in whole PCOS and CON groups can be find in the supplementary materials (Tables S2–S5)
Summary
Polycystic ovary syndrome (PCOS) is a complex metabolic disorder that occurs in 15–20% of women of reproductive age [1]. Clinical and/or biochemical hyperandrogenism, oligoovulation, and polycystic ovary morphology in ultrasound examination constitute the key factors of syndrome symptomatology, according to the 2003 Rotterdam criteria [2]. Clinical implications of PCOS include numerous endocrine, metabolic and reproductive disorders [3]. Insulin resistance (IR), and lipid metabolism disturbances are associated with complications often observed in PCOS. PCOS is considered to be a risk factor for type 2 diabetes mellitus (DM2), metabolic syndrome (MS), accelerated atherosclerosis, and cardiovascular diseases [6,7,8]. Central obesity aggravates endocrine and metabolic disorders in PCOS [9,10]
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