Abstract
The glucose uptake, lactic acid and pyruvic acid production, glycogen synthesis, oxygen uptake and carbon dioxide production were studied in leucocytes from 54 nondiabetic and 30 diabetic subjects. In normal leucocytes the magnitude of these parameters, except the CO 2 production, was influenced by the concentration of leucocytes used in the individual experiments, and decreased with increasing cell concentration. In diabetic leucocytes a similar dependency was found for the oxygen uptake and pyruvic acid production, but not for the glucose uptake, lactic acid production and glycogen synthesis, leading to the situation that these parameters were lower than in normal leucocytes at low cell concentrations, while the reverse was true at high leucocyte concentrations. The lower glucose uptake, lactic acid production and glycogen synthesis of diabetic leucocytes are not thought to be secondary to a defective transport mechanism for glucose.
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