Effect of ceftizoxime sodium on bacteriological and serum interleukin-6 and hypersensitive C-reactive protein in patients with acute bacterial infection

Abstract

Objective To investigate the bacteriological effect of cefazoxime sodium on acute bacterial infection and the effect of cefazoxime sodium on serum interleukin 6 (IL-6) and hypersensitive C reactive protein (hs-CRP) levels. Methods From January 2017 to August 2017, a total of 180 patients with acute bacterial infections were selected and divided into control group (90 cases) and observation group (90 cases) by the random digital table method. Ceftriaxone sodium was injected intravenously in control group (once 2.0 g, 2 times per day), while in observation group, cefazoxime sodium (once 2.0 g, 2 times per d) was injected intravenously. The bacteriological efficacy and serum IL-6 and hs-CRP levels before and after treatment were compared between the two groups. Results The effective rates of control group and observation group were 92.22% and 93.33%, respectively (χ2= 1.267,P = 0.058). There was no significant difference in positive rate of bacterial culture and bacterial clearance rate between the two groups (χ2= 1.274,P = 0.062;χ2= 2.266,P= 0.067). The levels of serum IL-6 in control group and observation group were significantly lower than those before treatment, with statistically significant difference (t= 12.471, P = 0.032;t = 13.892,P= 0.031). The levels of hs-CRP in the control group and observation group were significantly lower than those before treatment (t= 11.533,P= 0.023; t = 14.791,P= 0.019). Conclusions Cefazoxime sodium is effective in treatment of acute bacterial infection, which is similar to that of ceftriaxone sodium, and could significantly reduce the levels of serum IL-6 and hs-CRP. Key words: Ceftizoxime sodium; Bacteriological efficacy; Interleukin-6; Hypersensitive C-reactive protein