Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis

Jin-Jian Xu,Jin-Jian Xu,Wei-Yang Bai,Pian-Pian Zhao,Xing-Wei Zhang,Zhi-Min Ying,Xiao-Wei Zhu,Hou-Feng Zheng,Xue-Jin Xu,Mo-Chang Qiu,Ke-Qi Liu

doi:10.1186/s12944-019-1018-3

Abstract

BackgroundCD14 polymorphisms are associated with an increased risk of cardiovascular events. So far, many studies have been conducted, whereas the results were not always consistent.Materials and methodsTwenty-six articles involving thirty-seven datasets were recruited to evaluate the association between rs2569190 (9413 patients and 7337 controls), C-159T (4813 patients and 2852 controls) polymorphisms and cardiovascular diseases in a meta-analysis. The random or fixed effect models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals.ResultsThe strongest association was observed between rs2569190 and CVD in overall population (T vs. C, OR = 1.169, 95% CI: 1.087–1.257, p = 2.44 × 10− 5). Analysis after stratification by ethnicity indicated that rs2569190 was related to CVD in East Asian population (T vs. C, OR = 1.370, 95% CI; 1.226–1.531, p = 2.86 × 10− 8) and a potential relationship in European (T vs. C, OR = 1.100, 95% CI: 1.019–1.189, p = 0.015). In the stratification of endpoints, the associations were found in CHD subgroup (T vs. C, OR = 1.357, 95% CI: 1.157–1.592, p = 2.47 × 10− 7) and in AMI subgroup (T vs. C, OR = 1.152, 95% CI: 1.036–1.281, p = 0.009). However, we did not find any association between C-159T polymorphism with cardiovascular disease under any model.ConclusionsThe SNP rs2569190 significantly contribute to susceptibility and development of cardiovascular disease, particularly in the East Asian population and in the subtype CHD group, in addition, a potential association was observed in the AMI group, T allele acts as a risk factor for cardiovascular disease.

Highlights

Cardiovascular disease (CVD) is a major public health problem owing to associate increased risk of human mortality [1]
Analysis after stratification by ethnicity indicated that rs2569190 was related to CVD in East Asian population (T vs. C, odds ratios (ORs) = 1.370, 95% 95% confidence interval (CI); 1.226–1.531, p = 2.86 × 10− 8) and a potential relationship in European (T vs. C, OR = 1.100, 95% CI: 1.019–1.189, p = 0.015)
In the stratification of endpoints, the associations were found in CHD subgroup (T vs. C, OR = 1.357, 95% CI: 1.157–1.592, p = 2.47 × 10− 7) and in Acute myocardial infarction (AMI) subgroup

Summary

Introduction

Cardiovascular disease (CVD) is a major public health problem owing to associate increased risk of human mortality [1]. By far the most common cause of acute coronary syndrome (ACS) is atherosclerosis and coronary artery stenosis, these lesions are the pathological foundation of CAD [2]. According to the number of coronary artery stenoses and the diverse clinical manifestation, CVD was †. Full list of author information is available at the end of the article defined to various clinical phenotypes (like coronary heart disease (CHD), acute myocardial infarction (AMI), myocardial infarction (MI) and so on [3]). Atherosclerosis is a pathological condition that underlies several important averse vascular events including coronary artery disease (CAD), stroke, and peripheral arterial disease, responsible for most of the cardiovascular morbidity and mortality [5]. Many studies have been conducted, whereas the results were not always consistent

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Discussion

Conclusion