Abstract
BackgroundSo far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility.MethodsWe performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were employed to assess the association of CCR5-Δ32 polymorphism with HIV-1 susceptibility.ResultsCompared with the wild-type CCR5 homozygotes, the pooled OR for CCR5-Δ32 heterozygotes was 1.02 (95%CI, 0.88–1.19) for healthy controls (HC) and 0.95 (95%CI, 0.71–1.26) for exposed uninfected (EU) controls. Similar results were found in stratified analysis by ethnicity, sample size and method of CCR5-Δ32 genotyping.ConclusionsThe meta-analysis indicated that HIV-1 susceptibility is not significantly affected by heterozygosity for CCR5-Δ32.
Highlights
Inter-individual variability in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection, transmission, disease progression, and response to antiviral therapy has been attributed to host variability in multiple genes [1]
People homozygous for chemokine receptor 5 (CCR5)-D32 are naturally resistant to R5 HIV infection and the heterozygous state is associated with up to 2–4 years delay in disease progression [4]
Some studies have reported that CCR5-D32 heterozygotes could be protective against HIV transmission [8,9,10,11,12,13,14,15], whereas others have not confirmed that [16,17,18,19,20,21,22,23,24,25,26,27,28]
Summary
Inter-individual variability in susceptibility to HIV-1 infection, transmission, disease progression, and response to antiviral therapy has been attributed to host variability in multiple genes [1]. People homozygous for CCR5-D32 are naturally resistant to R5 HIV infection and the heterozygous state is associated with up to 2–4 years delay in disease progression [4],. Some studies have reported that CCR5-D32 heterozygotes could be protective against HIV transmission [8,9,10,11,12,13,14,15], whereas others have not confirmed that [16,17,18,19,20,21,22,23,24,25,26,27,28]. Many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. No definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-D32) can affect HIV-1 susceptibility
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