Abstract
Three groups of 10 water-deprived female rats received access to solutions of caffeine (0.5 mg/ml), ethanol (5% w/v), or water, after i.p. injection of the neuropeptide and hormone cholecystokinin octapeptide (CCK-8; 0.5-4.0 µg/kg). Behavioral displays associated with intake of these fluids were quantified with an instantaneous time-sampling observational technique. CCK-8 dose-dependently reduced intake of ethanol solution, but not intake of caffeine solution or water. Feeding behavior reliably (p A.05) decreased after caffeine consumption, and activity level increased. Chemically induced anorexias were specific to ingesta; CCK-8 did not affect caffeine or water intake, or caffeine-induced anorexia, but it did inhibit ethanol intake and associated feeding behavior.
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