Abstract
Experiments on rabbits showed that intravenous injection of dyes of the thionine series (toluidine blue, azure A, 1,9-dimethylmethylene blue) causes hypofibrinogenemia, a decrease in the concentration of factors of the prothrombin complex, thrombocytopenia, and a decrease in the index of platelet adhesion against the background of slowing of the time of thrombus formation. The blood heparin tolerance and the free heparin concentration were sharply reduced. It is suggested that the hypocoagulation effect of the cationic dyes on the blood is due to thrombocytopenia and to a decrease in the aggregating activity of the platelets.
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