Abstract
The secretory epithelial cells of the seminal vesicle in the normal rat contain an elaborate system of rough-surfaced endoplasmic reticulum. Upon castration regressive changes occur; these consist of a gradual detachment of the ribosomes from the membrane profiles with a nearly complete degranulation of the membranes in advanced stages. Part of the ribosomes then seem to be freely dispersed in the cytoplasm as single particles or in clusters. In the epithelial cells of the prostate similar changes can be observed after castration. The vas deferens of the normal rat contains cells with endoplasmic reticulum which is only partially covered by ribosomes; after castration a complete degranulation of the membrane profiles takes place. It is concluded that the extent of ribosomal population of the ergastoplasmic membranes in various target epithelia is controlled by androgens.
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