Abstract
IN CONNECTION WITH A STUDY of the effect of early ovariectomy upon the Jackson Laboratory dilute brown strain of mice, nodular hyperplasia of the adrenal cortex similar to that which occurred in the females (i) was noted in a few castrate male mice. An attempt was made to determine the regularity and behavior of the hyperplasia in the male and also to see if there was any indication of sexual stimulation when this was present. The adrenals, the accessory sex glands and in some cases the pituitary, thyroid, parathyroid and thymus were saved for study in serial section. The skins were fixed and the growth of mammary rudiments observed. Some of the mammary glands were studied histologically. Forty males were castrated at birth and 60 at later ages. This is a report on those which have died or have been killed up to the present time.
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