Abstract
The in-vitro effects of methanolic extract (MCSL) and aqueous infusion (ACSL) of the leaves of C. sieberiena on the motility of the rat intestines were studied and compared with those of C. acutifolia(MCAL and ACAL) “Senna”. All the extracts and infusion relaxed the ileum dose-dependently. Their effects were blocked by tolazoline, indicating that á–adrenergic receptors were involved. MCSLcontracted the colon dose-dependently and was blocked by atropine(1.7x10-8 M) and nifedipine (2.8x10-10M). ACSL contracted this segment at 2.0-8.0 mg/ml and relaxed it at 8.0-16.0mg/ml. Itsrelaxant effect was blocked by tolazoline (1.0x10-6M), indicating the involvement of á– adrenergic receptors . MCAL had a slight relaxant effect on the colon, while ACAL contracted it dose dependently and was blocked by promethazine (3.1x10-8M) and nifedipine (2.8 x 10-8M), indicating that H1-receptor stimulation and increased intracellular calcium ion concentration are involved. MCSL was more potent than ACAL, while ACSL and ACAL were equipotent in contracting thecolon. With proper processing C. sieberiena can be substituted for C. acutifolia.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
