Abstract
The effect of carbon particles on survival and hematological recovery of x-irradiated mice was studied. The administration of carbon particles, in the range of 5-15 mg per mouse, 24 hr before irradiation showed good protection against 600 R of x-rays. Similar protection was also observed in the mice which received 5 mg of the particles 3 hr after irradiation. The initial radiation-induced depression in splenic weight was partly prevented in the mice injected intravenously with 10 mg of carbon particles 24 hr before irradiation (500 R). The number of erythrocytes in the protected mice decreased similarly as observed in the irradiated control mice. But carbon particles promoted the subsequent early recovery in the number of erythrocytes. On the other hand, the number of erythrocytes in the unprotected mice was still decreasing. The effect of carbon particles on the decrease in the number of leukocytes was similar to that of erythrocytes except that the former showed a quicker recovery. As a possible explana...
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