Abstract
Abstract Bone tissue engineering has been area of substantial research since few decades but still a gap exists when it comes to strength and healing tendency of biomaterials with respect to age group, accidental complications etc. Many researches are yet in progress to design a perfect material for bone regeneration. Our attempt in the present study is to develop a porous hybrid material based on Chitosan(CS)/Polyvinyl Alcohol(PVA)/ Beta Tricalcium Phosphate (β-TCP) composite matrix incorporated with various carbon based fillers i.e. Graphene Oxide(GO, Reduced Graphene Oxide (RGO), Carbon Nanotube(CNT) . Scanning electron microscopy (SEM) results of fabricated scaffolds revealed nearly threefold increase in pore diameter when the concentration of each carbon filler incorporated in CS/PVA/βTCP increased to 1%. Addition of fillers also demonstrated significant mineral depositions on samples when treated with SBF .The Ca/P ratio of deposited minerals on some scaffolds was found near 1.67, the stoichiometric ratio of natural bone apatite .Increase in carbon filler concentration in CS/PVA/βTCP matrix also increased the compressive modulus of scaffold.
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